ORF3c is expressed in SARS-CoV-2-infected cells and inhibits innate sensing by targeting MAVS.
Müller M, Herrmann A, Fujita S, Uriu K, Kruth C, Strange A, Kolberg JE, Schneider M, Ito J, Müller MA, Drosten C, Ensser A; Genotype to Phenotype Japan (G2P-Japan) Consortium; Sato K, Sauter D.
EMBO Rep. 2023 Dec 6;24(12):e57137. doi: 10.15252/embr.202357137. Epub 2023 Oct 23.
The sensitivity of rapid tests for SARS-CoV-2 antigen—association with clinical manifestations, viral load, and sublines.
Knies K, Wagenhäuser I, Hofmann D, Rauschenberger V, Eisenmann M, Reusch J, Flemming S, Andres O, Petri N, Topp MS, Papsdorf M, McDonogh M, Verma-Führing R, Scherzad A, Zeller D, Böhm H, Gesierich A, Seitz AK, Kiderlen M, Gawlik M, Taurines R, Wurmb T, Ernestus RI, Forster J, Weismann D, Weißbrich B, Liese J, Vogel U, Kurzai O, Dölken L, Gabel A, Krone M.
Dtsch Arztebl 2023. 2023 Aug 25. doi: 10.3238/arztebl.m2023.0185.
Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5.
Krenn F, Dächert C, Badell I, Lupoli G, Öztan GN, Feng T, Schneider N, Huber M, Both H, Späth PM, Muenchhoff M, Graf A, Krebs S, Blum H, Durner J, Czibere L, Kaderali L, Keppler OT, Baldauf HM, Osterman A.
Med Microbiol Immunol. 2023 Aug 10. doi: 10.1007/s00430-023-00775-8.
Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages.
Osterman A, Krenn F, Iglhaut M, Badell I, Lehner A, Späth PM, Stern M, Both H, Bender S, Muenchhoff M, Graf A, Krebs S, Blum H, Grimmer T, Durner J, Czibere L, Dächert C, Grzimek-Koschewa N, Protzer U, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2023 Aug 10. doi: 10.1007/s00430-023-00774-9.
Longitudinal SARS-CoV-2 neutralization of Omicron BA.1, BA.5 and BQ.1.1 after four vaccinations and the impact of breakthrough infections in haemodialysis patients.
Platen L, Liao BH, Tellenbach M, Cheng CC, Holzmann-Littig C, Christa C, Dächert C, Kappler V, Bester R, Werz ML, Schönhals E, Platen E, Eggerer P, Tréguer L, Küchle C, Schmaderer C, Heemann U, Keppler OT, Renders L, Braunisch MC, Protzer U.
Kidney Journal. 2023;sfad147. doi: 10.1093/ckj/sfad147.
Comparable cellular and humoral immunity upon homologous and heterologous COVID-19 vaccination regimens in kidney transplant recipients.
Körber N, Holzmann-Littig C, Wilkens G, Liao BH, Werz ML, Platen L, Cheng CC, Tellenbach M, Kappler V, Lehner V, Mijočević H, Christa C, Assfalg V, Heemann U, Schmaderer C, Protzer U, Braunisch MC, Bauer T, Renders L.
Front Immunol. 2023 Mar 31;14:1172477. doi: 10.3389/fimmu.2023.1172477.
Analysis of SARS-CoV-2 Spike Protein Variants with Recombinant Reporter Viruses Created from a Bacmid System.
Cordsmeier A, Jungnickl D, Herrmann A, Korn K, Ensser A.
Int. J. Mol. Sci. 2023, 24(9), 8156; https://doi.org/10.3390/ijms24098156.
Immunologic Effect of Bivalent mRNA Booster in Patients Undergoing Hemodialysis.
Huth L, Schäfer L, Almanzar G, Lupoli G, Bischof M, Wratil PR, Stövesand T, Drechsler C, Keppler OT, Prelog M.
N Engl J Med. 2023 Feb 15. doi: 10.1056/NEJMc2216309. Epub ahead of print.
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.
Chen DY, Chin CV, Kenney D, Tavares AH, Khan N, Conway HL, Liu G, Choudhary MC, Gertje HP, O'Connell AK, Adams S, Kotton DN, Herrmann A, Ensser A, Connor JH, Bosmann M, Li JZ, Gack MU, Baker SC, Kirchdoerfer RN, Kataria Y, Crossland NA, Douam F, Saeed M.
Nature. 2023 Jan 11. doi: 10.1038/s41586-023-05697-2. Epub ahead of print.
Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma.
Keppler-Hafkemeyer A, Greil C, Wratil PR, Shoumariyeh K, Stern M, Hafkemeyer A, Ashok D, Hollaus A, Lupoli G, Priller A, Bischof ML, Ihorst G, Engelhardt M, Marks R, Finke J, Bertrand H, Dächert C, Muenchhoff M, Badell I, Emmerich F, Halder H, Spaeth PM, Knolle PA, Protzer U, von Bergwelt-Baildon M, Duyster J, Hartmann TN, Moosmann A, Keppler OT.
Nat Cancer. 2022 Dec 21. doi: 10.1038/s43018-022-00502-x. Epub ahead of print.
Nsp16 shields SARS-CoV-2 from efficient MDA5 sensing and IFIT1-mediated restriction.
Russ A, Wittmann S, Tsukamoto Y, Herrmann A, Deutschmann J, Lagisquet J, Ensser A, Kato H, Gramberg T.
EMBO Rep. 2022 Dec 6;23(12):e55648. doi: 10.15252/embr.202255648. Epub 2022 Oct 26.
Variable detection of Omicron-BA.1 and-BA.2 by SARS-CoV-2 rapid antigen tests.
Osterman A, Badell I, Dächert C, Schneider N, Kaufmann AY, Naz Öztan G, Huber M, Späth PM, Stern M, Autenrieth H, Muenchhoff M, Graf A, Krebs S, Blum H, Czibere L, Durner J, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2022 Nov 12;1-11. doi: 10.1007/s00430-022-00752-7. Online ahead of print.
Vaccine-hesitant individuals accumulate additional COVID-19 risk due to divergent perception and behaviors related to SARS-CoV-2 testing: a population-based, cross-sectional study.
Wratil PR, Kotter K, Bischof ML, Hollerbach S, Apak E, Kalteis AL, Nayeli-Pflantz T, Kaderali L, Adorjan K, Keppler OT.
Infection. 2022 Nov 10;1-11. doi: 10.1007/s15010-022-01947-z. Online ahead of print.
Accumulation of mutation in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.
Khatamzas E, Antwerpen MH, Rehn A, Graf A, Hellmuth JC, Hollaus A, Mohr AW, Gaitzsch E, Weiglein T, Georgi E, Scherer C, Stecher SS, Gruetzner S, Blum H, Krebs S, Reischer A, Leutbecher A, Subklewe M, Dick A, Zange S, Girl P, Müller K, Weigert O, Hopfner KP, Stemmler HJ, Bergwelt-Baildon von M, Keppler OT, Wölfel R, Muenchhoff M, Moosmann A.
Nat Commun. 2022; 13: 5586. Published online 2022 Sep 23. doi: 10.1038/s41467-022-32772-5.
Epidemiological and Serological Analysis of a SARS-CoV-2 Outbreak in a Nursing Home: Impact of SARS-CoV-2 Vaccination and Enhanced Neutralizing Immunity Following Breakthrough Infection.
Streibl BI, Lahne H, Grahl A, Agsten P, Bichler M, Büchl C, Damzog M, Eberle U, Gärtner S, Hobmaier B, Margos G, Hoch M, Jungnick S, Jonas W, Katz K, Laubert L, Schutt B, Seidl C, Treis B, Weindl D, Zilch K, Wildner M, Liebl B, Ackermann N, Sing A, Fingerle V.
Microorganisms. 2022 Sep 9;10(9):1809. doi: 10.3390/microorganisms10091809.
Virus variant–specific clinical performance of SARS coronavirus two rapid antigen tests in point-of-care use, from November 2020 to January 2022.
Wagenhäuser I, Knies K, Hofmann D, Rauschenberger V, Eisenmann M, Reusch J, Gabel A, Flemming S, Andres O, Petri N, Topp MS, Papsdorf M, McDonogh M, Verma-Führing R, Scherzad A, Zeller D, Böhm H, Gesierich A, Seitz AK, Kiderlen M, Gawlik M, Taurines R, Wurmb T, Ernestus RI, Forster J, Weismann D, Weißbrich B, Dölken L, Liese J, Kaderali L, Kurzai O, Vogel U, Krone M.
Clin Microbiol Infect. 2022 Aug 23:S1198-743X(22)00422-0. doi: 10.1016/j.cmi.2022.08.006. Epub ahead of print.
Improved SARS-CoV-2 Neutralization of Delta and Omicron BA.1 Variants of Concern after Fourth Vaccination in Hemodialysis Patients.
Cheng CC, Platen L, Christa C, Tellenbach M, Kappler V, Bester R, Liao BH, Holzmann-Littig C, Werz M, Schönhals E, Platen E, Eggerer P, Tréguer L, Küchle C, Schmaderer C, Heemann U, Renders L, Protzer U, Braunisch MC.
Vaccines (Basel). 2022 Aug 16;10(8):1328. doi: 10.3390/vaccines10081328.
Secondary zoonotic dog‑to‑human transmission of SARS‑CoV‑2 suggested by timeline but refuted by viral genome sequencing.
Hoppe JM, Füeßl LU, Hartmann K, Hofmann‑Lehmann R, Graf A, Krebs S, Blum H, Badell I, Keppler OT, Muenchhoff M.
Infection. 2022 Aug 20:1-7. doi: 10.1007/s15010-022-01902-y.
Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs.
Traube FR, Stern M, Tölke AJ, Rudelius M, Mejías-Pérez E, Raddaoui N, Kümmerer BM, Douat C, Streshnev F, Albanese M, Wratil PR, Gärtner YV, Nainytė M, Giorgio G, Michalakis S, Schneider S, Streeck H, Müller M, Keppler OT, Carell T.
Angew Chem Int Ed Engl. 2022 Jul 8. doi: 10.1002/anie.202204556. Online ahead of print.
Analysis of seven SARS-CoV-2 rapid antigen tests in detecting omicron (B.1.1.529) versus delta (B.1.617.2) using cell culture supernatants and clinical specimens.
Jungnick S, Hobmaier B, Paravinja N, Mautner L, Hoyos M, Konrad R, Haase M, Baiker A, Eberle U, Bichler M, Treis B, Okeyo M, Streibl B, Wimmer C, Hepner S, Sprenger A, Berger C, Weise L, Dangel A, Ippisch S, Jonas W, Wildner M, Liebl B, Ackermann N, Sing A, Fingerle V; Bavarian SARS-CoV-2-Public Health Laboratory Team.
Infection. 2022 May 20:1–7. doi: 10.1007/s15010-022-01844-5.
Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8.
Wu X, Xia T, Shin WJ, Yu KM, Jung W, Herrmann A, Foo SS, Chen W, Zhang P, Lee JS, Poo H, Comhair SAA, Jehi L, Choi YK, Ensser A, Jung JU.
mBio. 2022 Mar 28:e0040222. doi: 10.1128/mbio.00402-22.
SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells.
Yu Y-Q, Herrmann A, Thonn V, Cordsmeier A, Neurath MF, Ensser A, Becker C.
Cells. 2022; 11(8):1262. doi: 10.3390/cells11081262.
Impaired detection of omicron by SARS-CoV-2 rapid antigen tests.
Osterman A, Badell I, Basara E, Stern M, Kriesel F, Eletreby M, Öztan GN, Huber M, Autenrieth H, Knabe R, Späth PM, Muenchhoff M, Graf A, Krebs S, Blum H, Durner J, Czibere L, Dächert C, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2022 Feb 20. doi: 10.1007/s00430-022-00730-z. Epub ahead of print.
Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern.
Wratil PR, Stern M, Priller A, Willmann A, Almanzar G, Vogel E, Feuerherd M, Cheng CC, Yazici S, Christa C, Jeske S, Lupoli G, Vogt T, Albanese M, Mejías-Pérez E, Bauernfried S, Graf N, Mijocevic H, Vu M, Tinnefeld K, Wettengel J, Hoffmann D, Muenchhoff M, Daechert C, Mairhofer H, Krebs S, Fingerle V, Graf A, Steininger P, Blum H, Hornung V, Liebl B, Überla K, Prelog M, Knolle P, Keppler OT, Protzer U.
Nat Med. 2022 Jan 28. doi: 10.1038/s41591-022-01715-4. Epub ahead of print.
Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants.
Dächert C, Muenchhoff M, Graf A, Autenrieth H, Bender S, Mairhofer H, Wratil PR, Thieme S, Krebs S, Grzimek-Koschewa N, Blum H, Keppler OT.
Med Microbiol Immunol. 2022 Jan 21. doi: 10.1007/s00430-022-00728-7. Epub ahead of print.
Spike residue 403 affects binding of coronavirus spikes to human ACE2.
Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Müller JA, Krüger J, Heller S, Stenger S, Hoffmann M, Pöhlmann S, Kleger A, Jacob T, Conzelmann KK, Ensser A, Sparrer KMJ, Kirchhoff F.
Nat Commun. 2021 Nov 25;12(1):6855. doi: 10.1038/s41467-021-27180-0.
Reciprocal circulation pattern of SARS-CoV-2 and influenza viruses during the influenza seasons 2019/2020 and 2020/2021 in the Bavarian Influenza Sentinel (Germany).
Heinzinger S, Eberle U, Angermeier H, Flechsler J, Konrad R, Dangel A, Berger C, Sprenger A, Hepner S, Biere B, Liebl B, Ackermann N, Sing A.
Epidemiol Infect. 2021 Oct 26;149:e226. doi: 10.1017/S0950268821002296. Erratum in: Epidemiol Infect. 2022 Feb 11;150:e24.
SARS-CoV-2 N gene dropout and N gene Ct value shift as indicator for the presence of B.1.1.7 lineage in a commercial multiplex PCR assay.
Wollschläger P, Todt D, Gerlitz N, Pfaender S, Bollinger T, Sing A, Dangel A, Ackermann N, Korn K, Ensser A, Steinmann E, Buhl M, Steinmann J.
Clin Microbiol Infect. 2021 Sep;27(9):1353.e1-1353.e5. doi: 10.1016/j.cmi.2021.05.025. Epub 2021 May 24.
Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination.
Herrmann A, Jungnickl D, Cordsmeier A, Peter AS, Überla K, Ensser A.
Int J Mol Sci. 2021 Sep 22;22(19):10188. doi: 10.3390/ijms221910188.
In Vitro Rapid Antigen Test Performance with the SARS-CoV-2 Variants of Concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta).
Jungnick S, Hobmaier B, Mautner L, Hoyos M, Haase M, Baiker A, Lahne H, Eberle U, Wimmer C, Hepner S, Sprenger A, Berger C, Dangel A, Ippisch S, Hahner S, Wildner M, Liebl B, Ackermann N, Sing A, Fingerle V.
Microorganisms. 2021 Sep 16;9(9):1967. doi: 10.3390/microorganisms9091967.
Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern.
Osterman A, Iglhaut M, Lehner A, Späth P, Stern M, Autenrieth H, Muenchhoff M, Graf A, Krebs S, Blum H, Baiker A, Grzimek-Koschewa N, Protzer U, Kaderali L, Baldauf HM, Keppler OT.
Med Microbiol Immunol. 2021 Aug 20:1–13. doi: 10.1007/s00430-021-00719-0. Epub ahead of print.
Detection of the new SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in five SARS-CoV-2 rapid antigen tests (RATs), Germany, March 2021.
Jungnick S, Hobmaier B, Mautner L, Hoyos M, Haase M, Baiker A, Lahne H, Eberle U, Wimmer C, Hepner S, Sprenger A, Berger C, Dangel A, Wildner M, Liebl B, Ackermann N, Sing A, Fingerle V; Bavarian SARS-CoV-2-Public Health Laboratory Team.
Euro Surveill. 2021 Apr;26(16):2100413. doi: 10.2807/1560-7917.ES.2021.26.16.2100413. Erratum in: Euro Surveill. 2021 Oct;26(43):
Molecular SARS-CoV-2 surveillance in Bavaria shows no Omicron transmission before the end of November 2021.
Flechsler J, Eberle U, Dangel A, Hepner S, Wimmer C, Lutmayr J, Konrad R, Berger C, Weise L, Sprenger A, Zeitler J, Paravinja N, Angermeier H, Githure G, Schmidt S, Treis B, Okeyo M, Liebl B, Ackermann N, Sing A; Bavarian SARS-CoV-Public Health Laboratory Team.
Infection. 2022 Mar 1:1–6. doi: 10.1007/s15010-022-01767-1. Epub ahead of print.